Comparison of vaginal self?sampling and cervical sampling by medical professionals for the detection of <scp>HPV</scp> and <scp>CIN2</scp> +: A randomized study

Primary screening with human papillomavirus (HPV) test is more effective in reducing cervical cancer incidence than cytology and it also offers the opportunity to self-sample. We conducted a randomized study compare vaginal self-sampling sampling by medical professionals for HPV testing concerning prevalence of detection intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) 3 (CIN3+) primary screening. In total, 11 951 women aged 30-60 years were into two groups, 5961 (SS arm) 5990 (SMP arm). Sampling was performed RoversViba-brush SS arm cytobrush SMP arm. All samples applied an indicating FTA elute card analyzed using clinically validated real-time PCR (hpVIR). HPV-positive repeated about 6 months later same procedure as used initially. second referred colposcopy. The first did not differ between (6.8%, 167/2466) (7.8%, 118/1519) (P = .255). CIN2+ per 1000 screened 17 (43/2466 × 1000) (95%CI 13-24) 21 (32/1519 15-30) For CIN3+, 14 (35/2466 10-20) 15 (23/1519 10-23) conclusion, showed rate CIN3+ histology.